Neurobiology of Huntington's disease [electronic resource] :applications to drug discovery / edited by Donald C. Lo and Robert E. Hughes.
Contributor(s): Lo, Donald C | Hughes, Robert E., Ph.D.Material type: Computer fileSeries: Frontiers in neuroscience (Boca Raton, Fla.): Publisher: Boca Raton : CRC Press/Taylor & Francis Group, c2010Description: 312 p.,  leaves of col. plates : ill.ISBN: 9781420008258 (e-book : PDF); 9780849390005.Call number: 616.851 N494 Subject(s): Huntington's chorea -- Pathophysiology | Huntington's chorea -- Molelcular aspects | NeuropharmacologyGenre/Form: Electronic books.Online resources: Distributed by publisher. Purchase or institutional license may be required for access.
Includes bibliographical references and index.
ch. 1. Huntington's disease : clinical features and routes to therapy / Henry L. Paulson and Roger L. Albin -- ch. 2. Huntington's disease pathogenesis : mechanisms and pathways / Albert R. La Spada, Patrick Weydt, and Victor V. Pineda -- ch. 3. Protein interactions and target discovery in HD / John P. Miller and Robert E. Hughes -- ch. 4. Target validation for Huntington's disease / Seung P. Kwak, James K.T. Wang, and David S. Howland -- ch. 5. High-throughput and high-content screening for Huntington's disease therapeutics / Hemant Varma, Donald C. Lo, and Brent R. Stockwell -- ch. 6. Value of invertebrate genetics and biology to develop neuroprotective and preventive medicine in Huntington's disease / Christian Neri -- ch. 7. Mouse models for validating preclinical candidates for HD / X. William Yang and Michelle Gray -- ch. 8. Pharmaceutical development for HD / Richard J. Morse ... [et al.] -- ch. 9. RNA and DNA-based therapies for Huntington's disease / Meghan Sass and Neil Aronin -- ch. 10. Recombinant intrabodies as molecular tools and potential therapeutics for Huntington's disease / Ali Khoshnan ... [et al.] -- ch. 11. Biomarkers to enable the development of neuroprotective therapies for Huntington's disease / Steven M. Hersch and H. Diana Rosas -- ch. 12. Huntington disease : clinical experimental therapeutics / Ray Dorsey and Ira Shoulson.